Welcome to the NMRPREDICT-Server

 

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Norbert Haider and Wolfgang Robien







Sommerschule „1D- and 2D-NMR Spectroscopy in Liquids“ - September 2012







Vorlesungen im SS-2013




Latest News:



May 3rd, 2008: An analysis of the upgrades on NMRSHIFTDB and a few OPEN questions.

May 2nd, 2008: A list of 2,388 literature citations coming from approximately 6,000 compounds has been published, where NMR data have been reassigned during database generation and/or subsequent correction.

April 16th, 2008: The installation of my "Spectral Similarity Search Engine" has been finished - a detailed description can be found here.

April 11th, 2008: The registration for the NMR-Summerschool at Niederöblarn has been closed. During the next few days all preregistered colleagues will receive additional informations per email.

March 31st, 2008: Already 11 examples for severe NMR-misassignments online. More to come ! A search within the remark field of CSEARCH for the string 'reassign' revealed nearly 6000 (!!!) examples.

March 27th, 2008: Link to Carlos Cobas weblog added

March 25th, 2008: I am now in my new office - here you see some slides from the "Home of CSEARCH"

March 13th, 2008: I intend to show a few fotos of my new office, that everybody has an impression about the 'Home of CSEARCH' - stay tuned !

March 11th, 2008: Due to the help of the people from our computing center (ZID), the interruption of this server could be reduced to less than 1 hour, when moving from my old office to my new one.

March 3rd, 2008: A new page summarizing NMR-misinterpretations from the chemical literature is online - this page will be updated in regular intervals. Stay tuned, check back !

March 3rd, 2008: International Conference on LC-NMR and Related Techniques: Challenges in Biological Systems

March 1st, 2008: Registration for the "NMR-Summerschool 2008" at Niederöblarn possible

February 27th, 2008: Article in 'Spectroscopy Europe' about proton prediction - I had the honour to contribute to a joint project between Ray Abraham (University of Liverpool), Ernö Pretsch (ETH-Zürich), MESTRELAB RESEARCH (Spain), MODGRAPH (UK) and Wiley-VCh (Germany).

For 1D-examples see here ....
For HSQC and HMBC examples see here ....

February 12th, 2008: Peak number of http-requests exceeds 80,000 html & png - files per day !

February 12th, 2008: There is a web version of SCIFINDER available - for details see here

February 9th, 2008: A few remarks about a proposal of an 'InChIKey-resolver' - Tony Williams original posting and a few remarks on my blog.

February 6th, 2008: A new version of our SSSE (Spectral Similarity Search Engine) has been released yesterday. It is the successor of a system installed during May 2006. The new SSSE is able to search 1,5 billions spectral patterns in less than 1 second (peak performance), the average performance is at 600,000,000 spectral searches per second.

January 31st, 2008: Article in 'Spectroscopy Europe' about the decision process when adding new spectra into your reference database.

January 31st, 2008: Article in 'Spectroscopy Europe' on my cooperation with Wiley-VCh and eMolecules

January 31st, 2008: NMRPredict as 'robot-referee' - an example from the actual literature.

January 31st, 2008: IUPAC is pointing to our portal of NMR-reference spectra using InChIKeys - see here for their list of database providers

January 30th, 2008: It was a pleasure to me to work together with Ernö Pretsch (ETH-Zürich) and Ray Abraham (University of Liverpool) on proton prediction. Details of our successful cooperation can be found here as a press release.

January 30th, 2008: The improved version of a H1-Prediction engine has been implemented into MESTRELAB Research MNova-program. 1D- and 2D-structure verification examples are given (download the corresponding pdf's).

January 5th, 2008: I have started my 'CSEARCH NMR-data weblog' providing information about new developments within the CSEARCH-project.

January 2nd, 2008: Another massive CSEARCH-Upgrade - see here

December 18th, 2007: A "Structure_2_InChiKey" conversion tool has been implemented by Norbert Haider - it allows immediate lookup of experimental spectra.

December 14th, 2007: The University of Mainz in-house database has been indexed using InChIKeys and is also searchable via google. For an example click here.

December 14th, 2007: The last CSEARCH-upgrade for this year has been integrated today - a total number of 21,750 new spectra has been added during 2007.

December 12th, 2007: InChIKey-pages reflect actual situation within the CSEARCH-Project

Dezember 11th, 2007: InChIKeys for upcoming data in CSEARCH have been indexed by Google - for an example see here.

Dezember 1st, 2007: InChIKeys for upcoming data in CSEARCH online awaiting indexing by search engines. For an example see here.

November 29th, 2007: InChIKeys for upcoming data in CSEARCH are under preparation - will be online around December 1st, 2007. Indexing might take another couple of days. For an example: see here

November 29th, 2007: All 310,000 pages holding InChIKeys and their associated spectral information have been indexed by google.

November 28th, 2007: Already 126,000 pages from NMRPREDICT.ORC.UNIVIE.AC.AT holding InChIKeys and their associated spectral information indexed with google ! For a description see here ! As an example search for the spectral data of YLBURHKSBXHXES

November 28th, 2007: H1-prediction engines of E. Pretsch and R. Abraham and C13-prediction engine of W. Robien have been integrated into MestreNova leading to an excellent tool for structure-verification - for 1D-examples see here ....

November 27th, 2007: H1-prediction engines of E. Pretsch and R. Abraham and C13-prediction engine of W. Robien have been integrated into MestreNova leading to an excellent tool for structure-verification - for HSQC and HMBC examples see here ....

November 26th, 2007: Examples for beginners (read also comment-section): Basic C-13 NMR Data Interpretation

November 26th, 2007: Funny claims about data-checking (read also comment-section) or 'How to ignore nearly 50 years of an ongoing development'

November 19th, 2007: Inchikeys for CSEARCH & SPECINFO structures are available

November 19th, 2007: Another massive update of CSEARCH-Databases

Wolfgang Robien joins Editorial Board of "Spectrabase" 

700,000 spectra (MS,IR,NMR) of 500,000 compounds online - see also a press release

The scientific version of SPAM

Massive CSEARCH Update Campaign - learn more .....

A diversity analysis on real-world structures from the pharmaceutical industry

A follow-up of the NMRShiftDB debate

Spectrum predictions based on a small and on a large database

A few words about structural diversity - read it with some sense of humor .....


How many data do we need for prediction of CNMR-spectra ?

ACD's CNMR/Predictor Software performs at
1.59ppm on the NMRShiftDB-data

MODGRAPH's NMRPredict performs at
1.40ppm for the same dataset. This value is already corrected for a somewhat higher overlap, because within NMRPredict some 345,000 C-NMR spectra are available !

More on the NMRShiftDB discussion .....




What is available here ?

 

Web – based version of CSEARCH: Searchable by name, functional group and partial structure
CSEARCH technical reports
Ultrafast compound identification based on 16,400,000 carbon-NMR spectra calculated for the PUBCHEM-compounds and PUBCHEM-substances




A few words about quality and size of databases and performance of algorithms:





A Comparison of CSEARCH/NMRPredict and NMRShiftDB

A short version including the URL has been posted in the Guestbook of NMRShiftDB on March 14th, 2007 / 10.00 am. Every entry must be approved by the administrator on NMRShiftDB. On March 15th, 2007 / 13.00 there was still no approvement - therefore the above given header and the link to the page showing the analysis of data-quality of NMRShiftDB-data according to CSEARCH-criteria has been inserted here. (Wolfgang Robien, March 15th, 2007 at 1.20pm)

Another evaluation of NMRShiftDB-data together with a few remarks

Comparison of ACD CNMR/Predictor (1.59ppm overall) against CSEARCH (2.19/2.22ppm overall) on NMRShiftDB-data

NMRPredict performs at 1.40ppm on NMRShiftDB-data

Solvent-dependent predictions in CSEARCH

NMRPredict's response on Ryan' blog

My response on Chemspider's blog

How many data do we need for prediction of CNMR-spectra ?

A few words about structural diversity ....

Spectrum prediction based on a small and on a large reference collection


A follow-up of the NMRShiftDB debate

A diversity analysis on real-world structures from the pharmaceutical industry

Massive CSEARCH Update Campaign



Recommended Links:

 

 

NMRPredict available from MODGRAPH

NMRPredict on the Internet

NMRBenefit – a tool for optimizing spectrum assignment for extremely large databases

EMolecules - Ultrafast structure searching - the name has been changed - see their website for details [Remark Robien: My first intention was to name my spectral search engine based on the 16,4 millions carbon NMR spectra 'SPOOGLE' as an acronym based on 'SPectral gOOGLE' - it was a wise decision not to do so ! ]

NMR Processing software available from MESTREC

 


Last update: June 13th, 2007 by Wolfgang Robien
Last modification: March 13th, 2008
Wolfgang.Robien(at)univie-ac-at